study identifies new gut hormone regulating metabolism during fasting -凯发国际娱乐试玩

chinese researchers have identified a new gut-secreted hormone named famsin, which contributes to metabolic adaptations during fasting.

the intestines are responsible for nutrient absorption and orchestrate metabolism in different organs during feeding, and intestine-secreted hormones partly control the process. but it is unclear whether the intestines play a role in metabolism during fasting.

in the study published in cell research, researchers from tsinghua university and zhejiang chinese medical university named the newly-identified hormone famsin, meaning famine-survival hormone. during fasting, it is first shed from a protein called gm11437 and then binds to an olfactory receptor named olfr796. the famsin-olfr796 binding promotes the generation of glucose from certain non-carbohydrates and ketone bodies by breaking down fats and conserving energy during fasting.

meanwhile, blocking the signaling of the famsin-olfr796 binding improves the blood glucose level in diabetic mice, making famsin a potential therapeutic target for treating diabetes.

the researchers concluded their study demonstrates the communication between the intestines and other organs by a famsin-olfr796 signaling, critical to metabolic adaptations to fasting.